Why Your Mind Changes in Perimenopause
Why do mood swings, rage and brain fog feel so out of character during perimenopause? Dr. Elisabeth Wong explains how fluctuating estrogen, progesterone and testosterone act on brain receptors that regulate mood, memory and attention. She covers when antidepressants are truly indicated versus overprescribed, why brain fog shows up as real structural change rather than imagination, the ADHD and perimenopause overlap, and evidence-based non-hormonal options including mindfulness, exercise, sleep hygiene and self-compassion.
In this episode, we cover
- Why estrogen, progesterone and testosterone drive mood swings
- When antidepressants are genuinely indicated versus overprescribed
- What the 2026 Cambridge brain study reveals about menopause brain fog
- The link between ADHD diagnosis and the perimenopause transition
- Non-drug options that help: mindfulness, exercise and better sleep

Dr. Elisabeth Wong
Psychiatrist, Women's Mental Health
Resources mentioned
The Hormone-Brain Connection in Perimenopause
How shifting estrogen, progesterone and testosterone reshape mood, memory, focus and drive in midlife.
Antidepressants in Perimenopause: The Evidence
When medication genuinely helps, and why a full biopsychosocial assessment should come first.
Non-Hormonal Tools for Mood and Brain Fog
Mindfulness, exercise, sleep hygiene and self-compassion, all with evidence for midlife women.
Ready to Reclaim Your Health?
If this episode resonated with you, explore EverCalm Menopause for evidence‑based mind–body tools that support heart‑healthy habits, better sleep and calmer days.



